palmoplantar psoriasis versus eczema: major histopathologic clues for diagnosis

background & objectives:  accurate differentiation of eczema and psoriasis can be difficult, especially in areas of palm and sole. this study was designed to evaluate histopathological features and identify statistically significant parameters in distinguishing palmoplantar psoriasis from eczema of these regions in patients referring to razi skin hospital, tehran, iran. methods: in a cross-sectional study, the patients referring to razi skin hospital were subjected. biopsies of 36 patients with palmoplantar psoriasis and 16 patients with eczema of these regions were collected from archive of pathology.  all of the biopsies were examined blind to the clinical diagnosis by four dermatopathologists separately and data collection forms were completed. then obtained data were analyzed by spss software. results: the females were more affected than males. there was no difference on involving palm and sole between psoriasis and eczema. hypogranulosis (p